Tag Archives: Alzheimer’s

Prions, Misfoldings and Bears! Oh My!

Vacuoles caused by Prions
Background image shows the presence of vacuoles in brain tissue of a cow caused by a prion disease (BSE- Bovine Spongiform Encephalopathy). Original image by Dr. Al Jenny [Public domain], via Wikimedia Commons
There are many instances of diseases that are caused by a slight variation in the normal harmonious dance of cellular dynamics.  Take cancer as an example.  All healthy individuals have some malignant cells in their bodies inclining towards the cancerous state.  However in the everyday dance of cellular activity, these malignant cells are contained or destroyed by the immune system, and other harmonious cellular dynamics.  Only when the orchestrated cellular dance is off beat can these malignant cells evolve into full-grown tumors.

Prions  and misfolded proteins are another source of cellular miscoordination that can apparently result in many neurodegenerative diseases.    Although prions are considered infectious they are made of prion proteins (PrP) that  can exist in a healthy form (PrPc) and an infectious form (PrPsc).  Stanley B. Prusiner of University of California, San Fransisco purified prions in 1982 and won a Nobel Prize in 1997 for his work on prions.

PrPc is normally found throughout the body on the surface of cell membranes and has mainly an alpha-helical structure.   Although the normal function of PrPis very complex it appears to be important for cellular communication.  It is interesting to note that PrPbinds copper ions with a high affinity and recent studies performed in 2016 at Iowa State University by researcher Chi Fu Yen, et al., have revealed that exposure to copper can cause the misfoldings to occur.

Once the infectious prions begin to form (PrPsc) they interact with normal PrPand cause them to also misfold resulting in amyloid folds that aggregate into dense β- sheets that cause tissue damage and cell death.  Known human prion diseases include Creutzfeld-Jakob disease, Gerstmann–Sträussler–Scheinker syndrome, Fatal familial insomnia, and kuru.  These diseases are relatively rare, however, it is believed that more common neurodegenerative diseases such as  Alzheimer’s, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS) and frontotemporal lobar degeneration may also be caused by misfolding in other mamalian proteins with prion-like domains.

The complex folding of proteins into elaborate configurations is a vital part of health and can be thought of as a highly sophisticated form of origami.  Prions act like a chain of dominoes in that a distorted molecule can become a template upon which the next normal molecule can become distorted.  The process can start with exposure to small number of prions that then replicate exponentially, that is, one prion creates another, then the two prions create four and the four create eight.  As we have seen in previous posts, exponential processes can initially go unnoticed but eventually have explosive consequences, and in the case of prion diseases ultimately lead to death.

How to Stop or Prevent the Prion March

If we knew for sure how to stop the infectious march of prions it is possible that many neurodegenerative diseases that currently have no cure would become reversible.  This includes ALS, Alzheimer’s, and Parkinson’s.   Although scientists have not been able pin down a prevention strategy or a cure that would work for everyone with prion related diseases there are a couple of sources of evidence indicating the body has mechanisms for handling prions.  These sources are:

  1.  The progression of prion-like diseases such as ALS is not constant but rather appears to occur in spurts.  Thus there can be long intervals where there is no worsening of symptoms or in which symptoms improve.  This may indicate that processes normally used by the body to control the spread of prions are still functional.
  2.  There is evidence in the literature that spontaneous remission of symptoms in diseases with possible prion-like mechanisms has been observed by clinicians.   Spontaneous remissions of disease provide a wonderful ‘proof of concept’ that the body can unlock its ability to heal even diseases are said to be incurable.

One example of this is the case of Nelda Buss who was healed of ALS symptoms after progressing to a state of quadriplegia in 1985.  Her dramatic reversal occurred while being treated by a well-known Energy Healer named Dean Kraft.  Her case was investigated by ALS Untangled, an organization sponsored by the ALS Association  and the Motor Neuron Disease Association.

Dr. Richard Bedlack, Director and Neurologist at the Duke ALS Clinic in North Carolina led the investigation and found that Nelda Buss did in fact have ALS based on her detailed medical records and he states that today she has recovered at least 99% of her normal functionality.   In addition to her case Dr. Bedlack states in the video below that he has found an additional 15 cases of people who had ALS and appear to have been cured.

This video is a “must see” for anyone interested in understanding how unexpected disease reversals can be studied to provide insight into healing.  Watch the video for more details.

Currently Dr. Bedlack also has  a website that directly focuses on understanding ALS reversals.

Clearly there is hope for preventing and stopping the prion and prion-like march that may be leading to neurodegenerative diseases like ALS.

The Streetlight Effect on Chronic Disease Prevention

 Once upon a time scientific thinking was a virtue…

But science as currently conceived  can also be like the tale of drunkard’s search also called the streetlight effect.

“Researchers tend to look for answers where the looking is good, rather than where the answers are likely to be hiding. (David H. Freedman, 2010)”

 Clearly it is not just science that can get stuck, but society as a whole, as the gap between scientific pursuits and their impact on societal progress  widens.  Could it be that as the gap between the rich and poor increases, so does the gap between what scientists are working on and what is truly beneficial for the common person?

The Streetlight Effect on Science

We have been ingrained with the virtues of science over the past few hundred years to the extent that many believe it can even supplant religion as the ultimate venue for seeking truth.

However, in spite of its many achievements, it’s becoming clear that science too is often like the emperor without clothing when practiced within our current economic framework.  In this framework, most scientists require funding in order to sustain themselves and their research.  Thus if the sources of funding are constrained by the wealth gap, and the motivation for research is to develop profitable products (i.e. marketable drugs and marketable behavioral interventions), we end up with a streetlight effect upon scientists that can limit the scope of the solutions they find (i.e. profitable solutions vs better but unprofitable solutions) .

Profitable vs Unprofitable Solutions to Problems

You may ask, “How can an unprofitable solution be good?”  It is all a matter of perspective.  For example, if I design a drug that a person with Alzheimer’s can take for life to reduce symptoms, I have a very profitable business.  I can patent the drug and people have to buy it from me.  There are barriers to keep people from getting the drug elsewhere or making it themselves at home.  However, if I work very hard to invent a behavioral intervention (i.e.  a lifestyle or multimodal stategy or perhaps a cognitively stimulating music / dance program) that completely prevents Alzheimer’s, and people can learn it on their own at home, I will be destined for the poor house.  Sure it is a better solution, but who in their right mind will work on it?  Who will spend good money on clinical trials and marketing for a superior but unprofitable product?

This is a huge dilemma for our society!

Unprofitable solutions are often the best for society as a whole but scientists may never seek them because of the streetlight effect.

Consider that the cost for the multi-center Diabetes Prevention Program (DPP) clinical trials has been estimated at $200 million over 10 years. This study showed that lifestyle intervention in the form of a 1 year program  consisting of 26 weekly sessions (20 sessions within the first 6 months and 6 sessions in the following 6 months) covering nutrition, weight loss, physical fitness and behavior modification was more effective than the drug Metformin, or the standard of care, for preventing pre-diabetics from becoming diabetics within 10 years.

Although it would seem that the results speak for themselves with 58% reduction in the incidence of diabetes ( up to 70% reduction for people over 60),  the justification for the DPP intervention comes not from the dramatic improvement in quality of life of the participants, but rather from demonstrated fact that insurers paying for the DPP can save on costs given the expenses associated with diabetes.

The effort to introduce prevention efforts for diabetes has been a very expensive 20 year battle that is still on going.  So where does that leave the future of prevention efforts for other chronic diseases such as heart disease, cancer, lower respiratory diseases, stroke, and Alzheimer’s?

Chronic Disease Prevention

Most people already accept that our economic system and it’s search for profitable solutions will result in the creation of environments where chronic diseases that could have been easily prevented flourish.  In this framework, things that exist in abundance become worthless. For example the air that we breathe is vital for healthy living but as of yet has little economic worth because of its abundance.

In the YouTube video, “Pay for the Air you Breathe,” the advertising agency Leavingstone in Tbilisi, Georgia  delivered the following message:  “If  we don’t care about the air we breathe, sooner or later we’ll have to pay for it.” 

What can we do to speed up the process of adopting prevention strategies as the gold standard for world health?

One thing seems certain,  we cannot afford to keep waiting for the scientific process trapped by the streetlight effect and  enormous costs / delays of RCT trials  to provide definitive answers.  Clearly health science is at a disadvantage when risk factors such as possible carcinogens, pollutants, pesticides, household chemicals, food additives, sources of stress, electromagnetic field exposure and sedentary work policies can be introduced into our environment at a much higher rate than the many years of RCTs that are needed to show definitive cause and effect.

These are some of our options:

  1. Become your own health detective.
  2. Become an expert on your own individual health.
  3. Find ways to unite with chronic disease prevention and health promotion advocates worldwide.
  4. Find ways to unite with world-wide economic change advocates.
  5. Vote for people who understand the importance of the above perspective for the future of world health.

As a health detective you will learn to monitor your health and environment more closely to detect symptoms earlier and effect environmental and lifestyle changes needed to correct problems before medical intervention becomes necessary.  The key strategy is development of personal agency (the ability to initiate actions that improve ones personal outcomes).

As an expert on your own individual health your doctor becomes your ally rather than your savior.  You are in a better position to keep yourself healthy than the doctor.  Of course the doctor is an essential part of restoring health if you are sick, but you must be the driver of your health.

There is strength in numbers and we must find more ways to unite with the specific goal of chronic disease prevention and health promotion at the community, national and world level.  The National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) is a good place to begin the search for group involvement but must be greatly expanded upon in the years to come.  There are many groups already promoting multimodal chronic disease prevention strategies such as Sharp Again Naturally,  NEWSTART, AARP Global Council on Brain Health, etc.

Finally the elephant in the room must be addressed.  Human beings created our economic system and human beings can improve it. Sure it has been forged through suffering, sweat, tears and sacrifice throughout history largely through social structures based upon predatory-prey type relationships. But personal agency is our greatest asset and we must prevent our predatory-prey instincts from destroying the world and ourselves in the process.   Wealth inequality, slavery in the form of monetized debt and a profit driven economy that turns human beings into commodities are the greatest drivers of the world’s health problems.  The world needs a new vision of the future that includes health as the cornerstone.

Let’s begin building that vision.

Neuro-Genesis

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Your brain creates the world in which you live. Image by jdurham at morguefile.com.

Brand new baby brain cells (neurons) are crawling around inside your head as you read this!

This process, called neurogenesis, is very exciting because neurons create your world, and the birth of new neurons  is like a re-creation of the world taking place in your very own brain.  Let’s pause to consider this.

Most everyone is familiar with the account in Genesis of how the world was created.  In this account man was created on the sixth day.  But what is not mentioned is that once man was created, the whole world had to be re-created inside his head.   We cannot perceive objective reality directly.  In Kantian philosophy, this objective reality that is unknowable is referred to as the noumenal world.  Neurons are the living entities responsible for creating the subjective or phenomenal world which we can perceive.  The phenomenal world created by neurons is a simulation of the noumenon, and it includes everything that is perceivable through the senses, thoughts and emotions.

Thus each individual is the creator of a unique phenomenal world.  Although neurogenesis refers only to the birth of neurons in the brain, in reality we can extend the significance philosophically by thinking of it as neuro-Genesis, the re-creation of an individuals phenomenal world by the brain.

Unlike the noumenal world that is made up of objects, the phenomenal world is made up of memories.  It is very important to appreciate how our worlds are constructed by a constellation of living entities (neurons) each assembling memories like LEGO blocks to create a phenomenal world.

When neurons involved in this process die or malfunction our world shrinks.   This is why a patient with Alzheimer’s, though technically not blind, can forget how to see.  At first the patient may fail to recognize new acquaintances.  As the disease progresses, family members are not recognized, and finally even the concept of a face is forgotten as neurons continue to die or malfunction.

The Birth of Worlds

Research published this month by David Briley, et al., at the Mitchell Center for Neurodegenerative diseases, Department of Neurology, University of Texas Medical Branch, has shown that the birth of new neurons in the hippocampus may be responsible for preventing symptoms of Alzheimer’s Disease (AD) in individuals with brain degeneration  that is normally associated with full AD symptoms.  These rare individuals were referred to as  Non-Demented with Alzheimer’s disease Neuropathy (NDAN).  This research shows the importance of promoting the continuous birth of neurons throughout life for retaining mental health in increasingly toxic environments that we are creating.

The perspective I am promoting is that the birth of neurons in the brain is like the birth of new worlds, because these cells directly create our phenomenal world.  This can work in two ways.  The first is that death of cells which would cause our world to shrink can be counteracted.  The second is that our world can continue to expand as these new neurons find their place in our phenomenal world of memories.

In her Ted Talk (see link below), Sandrine Thuret mentions the strategies we can employ to promote the birth of new neurons in our brains.  She discusses research showing that aerobic exercise (running) is is a potent method for stimulating neuronal birth when compared to sedentary behavior.

Her list of do’s and don’ts for birthing brain cells include the following:

Do’s

  1. Learning
  2. Sex
  3. Running (Aerobic Exercise)
  4. Omega 3 fatty acids, blueberries, curcurmin, resveratrol (skin of red grapes, etc.
  5. Intermittent Fasting (increased spacing between last meal and first meal the next day)

Don’ts

  1. Stress
  2. Sleep Deprivation
  3. Alcohol
  4. Vitamin Deficiencies (A,B,E)
  5. High Sugar

Ultimately the best strategy for keeping your world growing is to protect both your old neurons as well as promoting the birth of new neurons.  Some neuroscientists think the birth of new neurons is hyped by the media of wishful thinkers.  According to these researchers the best advice is to take good care of the neurons you already have rather than hoping to gain new ones.  However, mounting evidence indicates we are in for more budding heads in the future, as the stream of baby neurons explore their place in the palace of our memories, our phenomenal world.  Enjoy!

Feed Me Fast

brain (1)Fasting and Brain Fitness

In some cases we can learn about the root cause of chronic disease by looking at how our environment and lifestyle has changed in the last few hundred years.  On an evolutionary time scale of billions of years, a few hundred years is a very short time, and is not long enough for the body design to catch up with environmental changes.

For example in our previous two posts we noted how the body evolved (or was designed ) for continuously challenging movements in the quest for finding food , finding mates, seeking safety from predators and fighting off competitors, and how our current sedentary lifestyle is at odds with our body.

Another anomaly driven by evolutionarily recent changes in food production is the over-abundance of food.  Our ancestors were more likely to face food scarcity, and a feast-or-famine type of existence.  When food was scarce, our ancestors bodies smoothly switched from using glucose as fuel to using stored fat for energy. This means that they were more likely to mobilize reserves of body fat resulting in a higher fat-free mass.

Now the over-abundance of food combined with sedentary lifestyles has created an epidemic of obesity in which the global population of overweight and obese people exceeds that of under-weight people.  Obesity is a risk factor for cardiovascular disease, diabetes, some cancers and emerging evidence suggests that it is also a risk factor for age related cognitive decline and possibly Alzheimer’s.  According to researchers like Mark Mattson (Chief of the Laboratory of Neurosciences at the National Institute on Aging)  and Bert Herring (Physician and Medical Writer), the root cause of the problem is not the excess storage of fat but rather, that the body needs fasting just like the muscles need exercise.

The idea of using fasting to improve health has existed for thousands of years as evidenced by the following quotes:

  • “Humans live on one-quarter of what they eat; on the other three-quarters lives their doctor.” – Egyptian pyramid inscription, 3800 B.C.
  • “Fasting is the greatest remedy– the physician within.”  Philippus Paracelsus, one of the three fathers of Western medicine
  • “A little starvation can really do more for the average sick man than can the best medicines and the best doctors.”  Mark Twain, in My Debut As a Literary Person.
  • “The best of all medicines is resting and fasting.”  Benjamin Franklin

There is evidence that fasting has positive effects on the whole body such as decreased inflammation, oxidative stress and asthma, increased insulin sensitivity and decreased risk of diabetes, lower heart rate and blood pressure, and increase in human growth hormone.

There is also evidence that fasting helps to improve cognitive function by stimulating the production of neurotrophic factors and can help prevent chronic diseases such as Alzheimer’s and Parkinson’s.

According to Mark Mattson, the key to understanding how this works is to appreciate that our bodies have another mode of operation where energy is derived from fat metabolism (ketosis) rather than from glucose metabolism (glycolysis).  When we eat three meals a day our bodies never switch over to this powerful mode of operation, because it takes 10 to 12 hours of fasting before the bodies glycogen stores are used up.

Fat is the Wealth of the Body

Every-day-life analogies for these two modes of operation would be like work vs vacation  or like being employed vs unemployed.  When you are in work mode you  save cash for vacations or unexpected loss of income.   As you can see from this example,  each mode of operation  entails a different set of priorities and tasks.

Likewise, fat is the stored wealth of the body and the bodies priorities shift depending on whether it is storing wealth (glycolysis) or using it (ketosis).  Think of a short fast as a vacation mode for your body, while a longer fast may be more challenging (i.e. unemployment).

Mark Mattson promotes the idea that fasting is a challenge to the brain.  This challenge promotes adaptive stress responses and changes in the brain similar to what is seen with vigorous exercise or cognitively challenging stimuli.  This makes sense from an evolutionary perspective.

Using our analogy, an unemployed person is challenged to learn new skills in order to compete for a new job.  Similarly the fasting brain responds to the challenge of acquiring more body wealth (fat), by generating neurotrophic factors that promote the development of new connections and that drive the transformation of stem cells into new brain cells in some regions of the brain.

The neurotrophic factor BDNF that is released during fasting also promotes the increase in the number of mitochondria inside cells.  Because mitochondria are the powerhouses of cells this increases the ability of neurons to grow and develop new connections.

How to Feed Your Brain Fast

Knowledge is power when properly applied, so what is the right way to incorporate fasting into your life.  Just like engaging in new physical activity it makes sense to discuss changes in lifestyle with your health care team.  Care must be taken if you have high calorie expenditure due to athletic endeavors, or if you are taking medications.

Fasting can generally be started by increasing the amount of time between your last meal of the day and your first meal of the subsequent day.  One could limit meals to an 8 hour window or less each day.  This is the approach that I have been using, although my window is currently more like 10 hours.

Another option is to skip the last meal of the day or the first meal of the day once or twice each week.  Just as an athlete must begin with light weights and progress to more difficult challenges in order to avoid injuries, so it is with fasting.  Learn more about it and proceed with caution in order to make sure the body is receiving its needed supply of nutrients.  It could be your ticket to a healthier you.

 

 

Excitement to Die For!

Photomontage_of_the_Marina_Bay_Sands_and_the_Merlion_with_fireworks,_Singapore_-_20100524
We are wired to seek excitement. So then how can it become toxic? Photo by William Cho. [CC BY-SA 2.0 ], via Wikimedia Commons
There are some things in life that seem good enough to die for.  The excitement we feel in these moments is hard to resist.  In general our bodies are wired to create excitement when it comes to activities that trigger survival instincts.  This includes warfare, hunting, eating, sex and any permutation of these activities.  In our modern world these activities are often morphed into civilized forms such as sports, video games, surfing the web, music, cuisine, etc.  But if our bodies are designed to handle a certain amount of excitement, can too much excitement become toxic, killing you before your allotted time?

Welcome to the frontline of the battle for health where you come up against your nemesis,  herein named Excitotoxicity!

Like the song “Counting Stars” says,

“And I I I I feel something so right by doing the wrong thing
And I I I I feel something so wrong by doing the right thing

I could lie, couldn’t I, couldn’t I?
Every thing that kills me makes me feel alive.”

Sure some things may truly be worth dying for, but others are simply enemy snares that rope us in and pull us down slowly over time.  There are a whole slew of behaviors that fall in this category such as overeating, alcohol, tobacco and drug use, sexual addiction.  These are well known to every one, and should probably be considered excitotoxins, but the excitotoxin targeted in this post is “free glutamate”, a flavor enhancer added to our processed foods that has 129 different names on food labels and is possibly implicated in a whole host debilitating diseases such as Alzheimer’s, Parkinson’s Disease, and other forms of dementia.

Ajinomoto_msg
The original free glutamate flavor enhancer developed in 1909 – MSG). Photo by Dynomat (Own work) [CC BY-SA 3.0 ], via Wikimedia Commons
 An excitotoxin is a substance that can damage or kill nerve cells by over stimulating them (i.e. exciting them to death) .  Over 70 types of excitotoxins have been identified (i.e. glutamate, aspartame, sodium caseinate, etc.)many of which are added to our food supply in the form of flavor enhancers.  They sneak into our foods, hidden behind names such as yeast extract, autolyzed yeast, vegetable protein, textured protein, natural flavor, carrageenan, and anything hydrolyzed.  ( See some lists here and here).  MSG is sold directly to consumers packaged as Accent, Sazon Goya, Vetsin, Marmite and Ajinomoto.

The official designation of the FDA for flavor enhancers such as MSG is GRAS ( Generally recognized as safe).  However the FDA recognizes that following symptoms are possible after large doses of MSG:

“short-term, transient, and generally mild symptoms, such as headache, numbness, flushing, tingling, palpitations, and drowsiness”

It does not appear that the FDA has performed long-term studies of the cumulative effects over many years of eating foods with added excitotoxins, nor have they studied the long-term effects on specific vulnerable populations such as children,  the elderly, and people who are genetically predisposed to neurodegenerative diseases such as Alzheimer’s, Multiple Sclerosis, Parkinson’s, ALS, etc.  A recent paper published May 2013 by Tadvi NA, et al., in the International Journal of Medical Research and Health Sciences titled “Excitotoxin: Their role in health and disease” concluded the following:

There is considerable evidence based research pertaining to the neurodegenerative effect of excitotoxins to the human brain. Yet the autonomous food regulating bodies like FDA refuse to recognize the immediate and long-term danger to the public caused by the use of such excitotoxic food additives. Thus only means of protecting oneself from such type of neurological damage is to consume only unprocessed, fresh, whole, organic foodstuffs.

Did you know that some of the drugs used to help Alzheimer’s patients (such as memantine or Namenda) work by blocking the effects of glutamate?

What it all boils down to is this:

You have to become the expert on your own health because something that doesn’t affect the majority of the people could be killing you or making you age prematurely.  You need to become your own health detective.

Redline_Excitement
Overly exciting your brain cells with excitotoxins may cost you down the road! Photo by Michael Gil from Calgary, AB, Canada (Redline Excitement) [CC BY 2.0], via Wikimedia Commons
This process starts by carefully reading all the labels on the foods you buy and possibly rejecting foods that are amazingly , excitingly delicious.  Vitamin C may also help protect against the effects of exposure to excitotoxins.

Huggly For Health

The idea for the  Huggly Formulation came during the night seven days ago.   After working on the question of scarcity and abundance in natural economies during the previous day, my altered state of sleep hit upon a solution in the form of The Huggly Formulation.

The Huggly Formulation for Abundant Health

Alaska visit
Group hug! By English: U.S. Air Force Staff Sgt. D. Myles Cullen [Public domain1], via Wikimedia Commons
In natural economies (such as the human body made up of trillions of individual cells) the fruit of production (i.e health) exists in abundance when the following five principles interact:

  • Harmonious orchestration of 7 fundamental virtues (i.e. Compassion, Faith, Truth, Justice, Security, Abundance and Joy).  This harmonious orchestration of virtues is the essence of Love.
  • Generation, preservation and celebration of diversity – continuous creation is the is the object of health.
  •  Invisible abundance supports visible abundance – natural abundance and health exist on many scales.  For example there are 100 billion neurons in the brain,  100 billion stars in the Milky Way galaxy, and 100 billion galaxies in the universe.
  • The “whole” is always greater than the “sum of the parts”
  • Each individual voice must be heard and each individual must be free.
Why “Huggly”

Other than the fact that it was recommended in a dream, the word huggly is used because it merges three other words – hug, snuggle and ugly.    The analogy is that a hug or snuggle are positive outcomes if the timing, duration and intensity are properly orchestrated.  If the hug is too intense or the timing and duration incorrect, things can turn ugly.  The same is true for all virtues relating to health.  They must be properly orchestrated to maximize positive outcomes, and prevent negative excess or scarcity.  For example:

  1. Faith without Truth is bankrupt – if you invest in a vision of the future that cannot come to fruition then your investment is lost.
  2. Compassion without Justice is incomplete – true compassion seeks correction and healing.
  3.  Security or Abundance without Joy is empty – the intangible joy is what makes life worthwhile.
  4. Joy without Compassion could be considered cruel.
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Strands twisted into rope. By Nevit Dilmen – GNU Free Documentation License

Like a rope with 7 strands, the 7 virtues need to be twisted together, hugging each other tightly in a septuple balanced helix for maximum health.  This spiral analogy keeps all the virtues in check, and represents the Huggly Formulation.

The Orchestration of a Healthy Memory

In a wonderful example of the role of orchestration on health published by CNN this week, Dr. Dale Bredesen, Director of the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA, was able to reverse the symptoms of Alzheimer’s in 9 out of 10 patients that participated in his pilot study.

Dr. Bredesen used a protocol that targets 36 sources of deficiency, imbalance and inflammation that  contribute to Alzheimer’s and Dementia.  According to the CNN article, “Bredesen said that most of the study participants had between 10 and 24 problems that needed correcting.”  The article goes on to state that,

“The effect of focusing on so many targets at once runs counter to what Bredesen said is a prevailing — and flawed — notion of identifying single targets to treat a disease caused by many factors.”

This exciting research brings hope to many who are suffering from dementia, and points to a new development in medicine whereby early Alzheimer’s may be treated by personalized health matrices that include

  1. Low glycemic, low grain, anti-inflamatory diets
  2. 30 to 60 minutes of exercise 4 to 6 days per week
  3. 12 hours a day of fasting between dinner and breakfast and at least 3 hours between dinner and bedtime
  4. Prebiotics to nourish good GI bacteria and probiotics to replenish healthy bacteria
  5. Stress reduction through yoga, meditation or music
  6. 8 hours of sleep per night and the possible use of melatonin and tryptophan
  7. Brain stimulation through the use of interactive software from companies such Posit Science.
  8. Chelation for heavy metal toxicity
  9. Ensure nocturnal oxygenation and treat sleep apnea
  10. Hormone supplements if needed to improve hormone balance
  11. Other supplements such a vitamin D3, K2 (see the full protocol in Table 1 of this link)

Although the specific protocol used by Dr. Bredesen should only be used under a doctor’s supervision, we can see that many elements of the protocol point to the importance of understanding how to properly orchestrate a balanced and virtuous lifestyle.

The Huggly Formulation provides a high level template that may serve as a scaffold  for designing and understanding complete lifestyle orchestration for maximum health.

Stay tuned for future posts on The Huggly Formulation.

Don’t forget to stay huggly, and have a merry Christmas!